EVIDENCE LEVEL 1B
Hyperthermia Treatment for
Loco-regional modulated electro-hyperthermia (mEHT) in combination with palliative radiotherapy for superior pain relief and increased radiological response.
Hyperthermia significantly improves relief of painful bone metastases to radiotherapy, increasing the 3 month complete response from 7.1% in RT alone, to 37.9% in the combination group; and almost double the amount of patients achieved a zero pain score (BIP) in the HT + RT group;
with pain relief lasting 3x longer, viz. 7.9 weeks VS 24 weeks and beyond trial follow up.
Level 1 Evidence: Phase III Prospective Randomized Controlled Trial
3 Months Complete Response %
Time to Pain Progression
Comparing the Effectiveness of Combined External Beam Radiation and Hyperthermia Versus External Beam Radiation Alone in Treating Patients With Painful Bony Metastases
Patients were randomized to RT-alone (n=28) and RT + HT (n=29). At 3 months after treatment the RT + HT patient group showed a significant higher complete response (CR) than the RT-alone group, i.e., 37.9% vs. 7.1% [P=0.006; CR defined as a zero score on the Brief Pain Inventory (BPI)]. Also, the accumulated CR at the third month after treatment was higher for the RT+HT group, i.e., 58.6% vs. 32.1% respectively (P=0.045).
Phase III Prospective Randomized Controlled Trial
3 Months Accumulated CR
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Three cases of bone ossification of the osteolytic lesions after radiation therapy plus hyperthermia. Image presented were established within a
2-month period after treatment
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