EVIDENCE LEVEL 1B
Hyperthermia Treatment for
Sarcoma
Regional Hyperthermia added to chemotherapy doubles the length of overall survival in patients with high-risk localised soft tissue sarcoma, and significantly improves the 9 year overall survival. (EORTC trial, ESMO 2015).
Phase III EORTC trial (EORTC 62961/ESHO; registered: NCT00003052)
5 Years Overall Survival %
Local Progression Free Survival %
Disease Free Survival %
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It was also shown to significantly improve the 9-year overall survival with no change in short term or long term toxicity between the two groups. In other clinical trials, regional hyperthermia when combined with chemotherapy, improved quality of life and survival statistics, and has scored well on several cost effective analysis.
“These findings strongly support adding regional hyperthermia to standard neoadjuvant chemotherapy in patients with localised high-risk soft tissue sarcoma. Induction with hyperthermia resulted in significantly increased Overall Survival (OS), Disease Free Progression (DFS), and Local Progression Free Survival (LPFS).”
Hyperthermia Plus Chemotherapy for Soft Tissue Sarcomas
Abbreviations: ChT: chemotherapy; CR: Complete Response; EIA: etoposide, ifosfamide, and doxorubicin; STS: Soft tissue sarcoma; RT: Radiotherapy; HT: Hyperthermia; RAS: Radiation Associated Sarcoma.
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